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Product description
Active substance:
Mifepristone
Pharmacological group:
Abortive (antigestagenic) drugs.
Mechanism of action of Mifeprex (Mifepristone)
This steroid medication has a mild androgenic action and blocks progestogenic receptors, reducing progesterone production. The medicine also improves the sensitivity of the muscular layer to prostaglandins, stimulates the manufacture and release of a strong anti-inflammatory cytokine (interleukin 8), and increases the contractility of the middle layer of the uterus (the myometrium).
The changed mucous membrane of the uterus forms when embryo implantation is rejected, and the embryo is subsequently expelled. The chemical also prevents ovulation, alters the endometrium, and halts zygote implantation.
Pharmacokinetic properties
Mifeprex (Mifepristone) is rapidly absorbed after being given orally (orally) at a dose of 200 milligrams. After an average of 1.3 hours, the drug reaches its peak concentration in the blood.
The half-life is 18 hours in length. Almost all of the medication is attached to proteins in the blood, particularly albumins and glycoproteins. The liver is responsible for Mifepristone’s oxidative biotransformation. Most of the drug is eliminated by feces, with 10% being eliminated via urine.
Indications for the use of Mifeprex:
- Medical termination of a physiological pregnancy as early as possible, up to 77 days of amenorrhea (in combination with Cytolog);
Inducing labor artificially to facilitate a successful delivery at term; - Preparing the cervix conservatively for a surgical abortion in the first trimester to soften and open it;
- In the event of intrauterine fetal mortality, inducing labor artificially when oxytocin and prostaglandin usage is contraindicated;
- Leiomyoma is a benign, monoclonal uterus tumor that often doesn’t grow larger than 12 weeks.
Contraindications to use:
- Pregnancy for more than 77 days;
- Pathological ectopic fertilization;
- Unconfirmed pregnancy.
Common contraindications include:
- Hereditary porphyrin disease;
- Severe bronchial asthma;
- Chronic liver or adrenal insufficiency;
- Individual intolerance to hormonal drugs;
- Severe anemia.
In the presence of inflammatory diseases, eclampsia, severe gestosis, incorrect positions, or large fetal sizes, Mifepristone as an inducer of labor is contraindicated.
Side effects
- Diarrhea;
- Abdominal pain;
- Headache;
- Severe allergic reaction (anaphylaxis);
- Anemia;
- Abnormal heartbeat;
- Chest pain;
- Gas (flatulence);
- Gastrointestinal bleeding;
- Hearing loss;
- Heart attack (myocardial infarction);
- Nausea;
- Vomiting;
- Constipation;
- Rupture of the uterus;
- Blood clot.
Features of interaction with other drugs
Mifepristone’s potential medication interactions have not been studied in detail. In contrast, the antibiotic Rifampicin, the hormone medication Dexamethasone, and a few anticonvulsants (Carbamazepine and Phenobarbital) are known to lower Mifepristone levels in the blood serum. In contrast, the blood concentration of antifungal medications like Itraconazole and Ketoconazole and the antibiotic Erythromycin increases.
Where can I get generic Mifeprex?
We provide an online resource where you may get Mifeprex and other abortion medications. We work hard to guarantee that our clients have a positive experience with their Medical Abortion at home without resorting to surgery.
What is the price of the Mifeprex tablet in dollars?
Mifeprex may be purchased from our site at a low price, and it will be delivered to your door promptly. To make your shopping experience as easy as possible, we also provide expedited delivery, overnight shipping, and other services.
What is the best place to get the Mifeprex kit?
A Mifeprex kit may be purchased with ease and comfort from the comfort of your own home by using the internet. Get a Mifeprex kit from our always-open online store.
Our products have been safe and effective since the Food and Drug Administration approved them. In addition, we preserve your privacy both online and off with our secure data and transaction system and our stealthy packaging.