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Product description
Active substance:
Misoprostol
Pharmacological group:
Prostaglandins (biologically active substances)
Mechanism of action of Cytotec (Misoprostol):
Buy Cytotec (Misoprostol) is not a natural steroid but has actions similar to prostaglandin E1. The chemical irritates the stomach lining and calms the uterus’s smooth muscles. This drug has the potential to protect cells from harm. In particular, it increases mucus and NaHCO3 production by the gastrointestinal mucosa. A direct blow to the parietal layer of the stomach mucosa caused this.
Misoprostol produces contractions of the smooth muscles of the myometrium, which in turn causes the cervix to expand and increase in tone. As a result, the contents of the uterus may be removed more efficiently and quickly, leading to a successful abortion.
Pharmacokinetic properties:
After taking Misoprostol (Cytotec), the drug is absorbed very instantly. As much as 85% of the drug is bound to proteins in the blood plasma. The drug’s metabolism in the liver and intestinal lining involves misoprostolic acid.
After 30–40 minutes, the highest concentration of the drug will be stable. Subsequently, the kidneys eliminate 80-85% of Misoprostol, and the bile eliminates the remaining 15-20%. The half-life is predicted to be anything from 20 to 40 minutes. When renal illness is present, the elimination half-life of a drug is prolonged by a factor of two.
Indications for Cytotec:
Cytotec (Misoprostol) is prescribed to patients who have been using nonsteroidal anti-inflammatory medicines (NSAIDs) for an extended period in order to treat acute gastric and/or duodenal ulcers. In addition, Misoprostol is often recommended when an individual is at high risk for developing an ulcer.
Pregnancies may be terminated using Cytotec and Mifeprex up to 77 days into the pregnancy.
Contraindications:
- Diseases of the cardiovascular system, kidneys, and liver associated with prostaglandin dependence;
- Individual intolerance;
- Glaucoma;
- Bronchial asthma;
- Endocrinopathies (diabetes mellitus, adrenal dysfunction, etc.);
- Hormone-dependent neoplasms;
- Anemia;
- Lactation and breastfeeding;
- Enteritis.
Children and adolescents under 18 years of age are prohibited from taking Misoprostol. In addition, when dehydrating the body, the drug should be taken with extreme caution.
Side effects
Abdominal discomfort, excessive gas production (flatulence), dyspepsia (nausea and vomiting), and stool problems are all possible GI complications (constipation, diarrhea). Reproductive system complications include menstrual cycle disturbances, abnormal uterine bleeding, and uncomfortable feelings in the lower abdomen caused by an active contraction of the central muscular layer of the uterus.
Misoprostol may cause adverse responses, including rash, swelling, itching, etc. The drug’s use in women also carries the risk of various side effects, including a change in body weight (both down and up), asthenia, weakness, and weariness. In addition, women beyond menopause have sometimes been reported to have convulsive contractions.
Features of interaction with other drugs
When used together, NSAIDs and Misoprostol might cause peripheral edema and elevated transaminases (ALT, AST). Diazepam, Antipyrine, Diclofenac, Aspirin, Piroxicam, Indomethacin, and Naproxen showed no clinical signs of interaction. Misoprostol usage elevates the blood level of Propranolol marginally.